Nanometric platforms for biomedicine – Multifunctional Magnetic Molecular Materials

Historical overview

From the grounds of a solid experience in molecular magnetic materials, some researchers in the M4 group shifted his interest to the emerging field of nanotechnology some 30 years ago. The first efforts were dedicated to the development of synthetic procedures for the control of crystal phase, size and shape of iron oxide nanoparticles that crystallized in a new patented method based on the use of polymers as precipitating matrix.

Soon it became evident that the most promising applications of these nanoparticles were in the biomedical field and the focus was set on these applications. The attention of the group was specially directed to hyperthermia therapy and, later on, a new line of research emerge: nanothermometry; as this is an essential tool for the advance in this field.

At present, the aims of the group are: 1) the development of multi-therapeutic tools for cancer including hyperthermia; 2) the development of luminescence nanothermometers with high spatial and time resolution; 3) the use of these nanothermometers for monitoring intracellular phenomena involving thermal processes.

Recent Achievements

Avoiding the Reticuloendothelial System

PEG-Copolymer-coated Iron Oxide Nanoparticles that Avoid the Reticuloendothelial System and Act as Kidney MRI Contrast Agents
Nanoscale, 2018, 10, 14153-64

Glucose Homeostasis on Type 2 Diabetes

Effect of Superparamagnetic Iron Oxide Nanoparticles on Glucose Homeostasis on Type 2 Diabetes Experimental Model
Life Sciences, 245, 117361, 2020

Molecular Logic

Lanthanide Luminescence to Mimic Molecular Logic and Computing through Physical Inputs
Adv. Opt. Mater. 2020, 8, 2000312

Hyperthermia

Magnetic hyperthermia with e-Fe2O3 nanoparticles
RSC Adv., 2020, 10, 28786

Intracellular Temperature Imaging

Real-Time Intracellular Temperature Imaging Using Lanthanide-Bearing Polymeric Micelles
Nano Lett. 20, 6466-6472, 2020

2D temperature imaging with high spatial and time resolution.

The group designs and produce temperature sensitive luminescence nanoprobes, and builds instruments for the detection of luminescence emission from this probe and conversion into 2D temperature imaging of the object of observation. The functional molecular groups of the probes are lanthanide complexes. The signal of the probes is transformed in absolute temperature data

Enhanced Hyperthermia therapy.

Based on a local application of small amounts of heat localized in certain intracellular sites such as mitochondria. It is expected that the generation of high enough temperature gradients on these sites could induce cell apoptosis, thus using an amount of heat considerable lower than that employed on actual hyperthermia treatment, which are based on whole tumour heating

Multi-therapeutical approach for cancer treatment.

Several kinds of cancer therapy are joined in a single iron-oxide-polymer nanoparticles to achieve a synergic therapeutical effect higher than that of individual therapies and the sum of them. Selected therapies include: Hyperthermia, Chemotherapy and Immunotherapy

Multitherapy of cancer from the intercept of nanotechnology and cell biology

PGC2018-095795-B-I00 ( 2019 – 2021) IP A Millan

Nanoparticles-based 2D thermal bioimaging technologies (NanoTBTech) 

FETOPEN-01-2016-2017, no.: 801305 (2018 – 2021) Coordinator: Luis Carlos

Local hyperthermia cancer treatment studies using a new temperature-imaging-hyperthermia microscopy instrument

H2020-MSCA-IF-2017 ( 2018 – 2020) Coordinator: Angel Millan

Redesigning biocatalysis: Thermal-tuning of one-pot multienzymatic cascades by nanoactuation (HOTZYMES)

FET-OPEN RIA 829162 (2019 – 2022) Coordinator: Valeria Grazu

A European Network for Connective Tissue Calcifying Diseases “EuroSoftCalcNet”

COST Action 16115. ( 2017 – 2021) Coordinator: Martin Ludovic.

Red de Investigación Nacional: NANOTECNOLOGÍA EN HIPERTERMIA TRASLACIONAL

RED2018-102626-T. MCIN (2019 – 2020) Coordinator: Daniel Ortega

Highlights

Scattering of spin waves by a Bloch domain wall: Effect of the dipolar interaction.

Victor Laliena, Athanasios Athanasopoulos and Javier Campo.

Historical overview

Recent Achievements

Avoiding the Reticuloendothelial System

Glucose Homeostasis on Type 2 Diabetes

Molecular Logic

Hyperthermia

Intracellular Temperature Imaging

Present Goals

2D temperature imaging with high spatial and time resolution.

Enhanced Hyperthermia therapy.

Multi-therapeutical approach for cancer treatment.

On-going projects

Multitherapy of cancer from the intercept of nanotechnology and cell biology

Nanoparticles-based 2D thermal bioimaging technologies (NanoTBTech)

Local hyperthermia cancer treatment studies using a new temperature-imaging-hyperthermia microscopy instrument

Redesigning biocatalysis: Thermal-tuning of one-pot multienzymatic cascades by nanoactuation (HOTZYMES)

A European Network for Connective Tissue Calcifying Diseases “EuroSoftCalcNet”

Red de Investigación Nacional: NANOTECNOLOGÍA EN HIPERTERMIA TRASLACIONAL

Highlights

Scattering of spin waves by a Bloch domain wall: Effect of the dipolar interaction.

New magnetic intermediate state, “B-phase,” in the cubic chiral magnet MnSi

Magnonic Goos-Hänchen effect induced by one dimensional solitons

Metastability and Creation of single chiral soliton states in monoaxial helimagnets

Large magnetocaloric effect in EuGd2O4 and EuDy2O4

Stability of Ag(III) towards Halides in Organosilver(III) Complexes

A novel method to obtain integral parameters of the orientation distribution function of textured polycrystals from wavelength-resolved neutron transmission spectra

Efficient Brownian oscillators and nanoheaters based on gallium-doped e-Fe2O3†

A new twist on an old ligand: a [Mn16] double square wheel and a [Mn10] contorted wheel

Building C(sp3) Molecular Complexity on 2,2’-Bipyridine and 1,10-Phenanthroline in Rhenium Tricarbonyl Complexes

Field induced slow magnetic relaxation in a zig-zag chain-like Dy(III) complex with the ligand o-phenylenedioxydiacetato

On new solvatomorphs of the metalloligand [Ni(o-van-en)]

Intermediate magnetic phase of the magnetoelectric compound (Ca,Sr)BaCo4O7 described with the superspace formalism

Dynamics of chiral solitons driven by polarized currents in monoaxial helimagnets

Design and optimization of a magnet for magnetocaloric refrigeration.

Lanthanide Luminescence to Mimic Molecular Logic and Computing through Physical Inputs.

Switching of the Chiral Magnetic Domains in the Hybrid Molecular/Inorganic Multiferroic (ND4)(2)[FeCl5(D2O)].

Molecular nanoclusters as magnetic refrigerants: The case of Fe-14 with very large spin ground-state.

Thermometry at the nanoscale.

Rational Electrostatic Design of Easy-Axis Magnetic Anisotropy in a Zn-II-Dy-III-Zn-II Single-Molecule Magnet with a High Energy Barrier.

Fluoride-Bridged {Gd-III M-3(III) (2)} ( M= Cr, Fe, Ga) Molecular Magnetic Refrigerants**.

A symmetric, triply interlaced 3-D anionic MOF that exhibits both magnetic order and SMM behaviour.

Spin-1/2 Quantum Antiferromagnet on a Three-Dimensional Honeycomb Lattice Formed by a New Organic Biradical F4BIPBNN.

Stability of skyrmion textures and the role of thermal fluctuations in cubic helimagnets: A new intermediate phase at low temperature.

Identifying early pathogenic events during vascular calcification in uremic rats.

Exploring through-bond and through-space magnetic communication in 1,3,2-dithiazolyl radical complexes.

Structural Insights into the Two-Step Spin-Crossover Compound Fe(3,4-dimethyl-pyridine)(2)[Ag(CN)(2)](2).

Tetra-n-butylammonium orotate monohydrate: knowleage-based comparison of the results of accurate and lower-resolution analyses and a non-routine disorder refinement.

Polymorphism of the dinuclear Co-III-Schiff base complex [Co-2(o-van-en)(3)]center dot 4CH(3)CN (o-van-en is a 96 salen-type ligand).

Real-Time Intracellular Temperature Imaging Using Lanthanide Bearing Polymeric Micelles.

What is a crystal to the new chemical crystallographer, after that first, automated structure analysis?.

An Investigation of Halogen Bonding as a Structure-Directing Interaction in Dithiadiazolyl Radicals.

A decanuclear [(Dy6Zn4II)-Zn-III] cluster: a {Zn-4(II)} rectangle surrounding an octahedral {Dy-6(III)}.

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Nanoparticles-based 2D thermal bioimaging technologies (NanoTBTech) 